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Urgent action is therefore needed whether through neuromodulation therapies, novel pharmaceutical drugs or even integrative phytotherapy to address this pervasive and debilitating condition

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One study found that MS patients had higher levels of Akkermansia and Acinetobacter and lower Parabacteroides compared to controls, and when these microbial communities were transferred to germ-free mice, the mice developed more severe EAE (the mouse model of MS) [184]

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Additionally, at steady state concentration (Css) of 800900 ng/mL, none of the patients with myelofibrosis experienced SOS when Cy was administered prior to Bu compared to 30% in patients conditioned with Bu followed by Cy 61